VirtualBox может управляться как через GUI-интерфейс, так и через командную строку.
Для расширения функций программы разработан специальный комплект SDK.
Параметры виртуальных машин описываются в формате XML и никак не зависят от того физического компьютера, на котором система работает. Поэтому виртуальные компьютеры формата VirtalBox легко переносить с одного ПК на другой.
При использовании на "гостевых" компьютерах операционных систем Windows или Linux можно воспользоваться специальными утилитами, значительно облегчающими переключение между физическим и виртуальными компьютерами.
Для быстрого обмена файлами между гостевым и физическим ПК можно создавать так называемые "разделяемые каталоги" (Shared folders), которые одновременно доступны из обоих этих машин.
VirtualBox позволяет подключать USB-устройства к виртуальным компьютерам, позволяя виртуальным машинам работать с ними напрямую.
VirtualBox полностью поддерживает протокол удалённого доступа RDP (Remote Desktop Protocol). Виртуальная машина может работать как RDP-сервер, позволяя управлять ею удалённо.

The virtual USB 2.0 (EHCI) device; see the section called “USB settings”.
VirtualBox Remote Desktop Protocol (VRDP) support; see the section called “Remote display (VRDP support)”.
Intel PXE boot ROM with support for the E1000 network card.
Experimental support for PCI passthrough on Linux hosts; see the section called “PCI passthrough”.
Установка:
Запустить VirtualBox, зайти в меню Файл » Свойства » Плагины и добавить скачанный файл, имеющий расширение .vbox-extpack

Программа сделана при помощи Portable-VirtualBox_v4.2.4-Starter_v6.4.9-Win_all.
Список отличий от официальной версии:
не требует установки, при запуске будет выбрана разрядность вашей системы, в панели задач появится значок VirtualBox, там можно будет выбрать дополнительные настройки по сохранению настроек программы, задать горячие клавиши, настроить запуск VirtualBox с поддержкой USB, настройки сети, языковые настройки, задать настройки по проверке обновления программы.

VMM: more work on improving the emulation of certain MSR registers (e.g. bugs #12224, #12544)
VMM: fixed a VERR_INVALID_RPL Guru Meditation when booting certain guests (bug #11350)
VMM: experimental support for SSE 4.1 / SSE 4.2 passthrough
VMM: fix for recent Linux kernels with software virtualization
GUI: experimental HID LEDs synchronization for Windows hosts
GUI: warn the user if the Oracle Extension Pack is not installed and the user tries to activate the remote display feature (bug #9104)
GUI: make sure that a minimized guest (using mini toolbar in fullscreen/seamless mode) keeps the minimized state (bug #12199)
GUI: popup banner’s “do not show this message again” check-box replaced with corresponding button
GUI: network adapter cables can now be connected/disconnected directly through the running virtual machine Devices / Network menu a Network status-bar indicator
GUI: the new VM wizard now proposes 64-bit guests on 64-bit hosts by default; better distinction between 32-bit OS types 64-bit OS types (bug #12533)
GUI: better error message if appliance import fails (bug #12657)
GUI: allow to set host-combination to ’None’ using the Global settings / Input page (bug #12730)
GUI: don’t switch the guest to a black screen during online snapshot merge (4.3 regression)
VBoxManage: when exporting an appliance, support the suppression of MAC addresses, which means they will be always recreated on import, avoiding duplicate MAC addresses for VMs which are imported several times
AHCI: fixed a VM hang during suspend under certain circumstances
AHCI: fixed a VM hang during online snapshot merge under certain circumstances
AHCI: fixed a bug which resulted in Windows XP guest hangs if a SATA CDROM is attached (bug #12417)
AHCI: fixed a Guru Meditation under certain conditions
AHCI: ejecting a CD/DVD medium failed under certain conditions
AHCI: disk hotplugging fixes
NAT: transparent handling of host sleep/resume and network configuration changes if the dnsproxy is enabled or if the hostresolver is used (bug #12441)
NAT: fixed crash and misbehaviour under some circumstances with ICMP packets having TTL=1
NAT Network: fixed IPv6 reassembly
NAT Network: ping proxy implemented
OVF: fixed reading of the OVF 0.9 section element (4.3 regression; bug #12345)
OVF: several fixes
3D: several fixes, multiscreen fixes (e.g. bug #9124)
3D: include 3D content in captured videos (bug #12666)
3D: include 3D content in captured screenshot (bug #11758)
VGA: proper handling of legacy graphics modes if the Guest Additions are active (bug #6649)
USB: fixed crash during isochronous transfer under rare circumstances
BIOS: better disk geometry handling of SCSI drives
API: fix crashes in Java API clients using the XPCOM binding, happened with output parameters only (bug #11232)
VBoxSVC: documented the handling of host power management events and added an extradata item for configuring the handling of the battery-low event (bug #9925)
VBoxSVC: fixed a bug which could trigger a crash if a VM snapshot was restored the second time and the VM has associated bandwidth groups (bug #12569)
VBoxSVC: properly detect ifconfig if located in /bin (bug #12713)
Shared Folders: fixed a failure to restore transient shared folders when starting a VM from a saved state (bug #12578)
Mac OS X hosts: fixed issue when the application icon was frozen in the dock if the bridging interface was not connected to a network (bug #12241)
Linux hosts: also consider the physical package ID when determining the number of physical CPU cores
Linux hosts / guests: don’t warn in kernel log if memory allocation fails (bug #11171)
Solaris hosts: fixed the autostart SMF script (bug #11720)
Windows hosts: fixes for non-ANSI code page user names and similar environment contents (bug #12596)
Windows hosts / guests: fixed setting and using a guest user’s process environment variables (relevant for Guest Control)
Windows Additions: fixed handle leaks in VBoxTray (bug #12563)
Windows Additions: fixed a crash while detecting active guest users
Windows Additions: fixed restoring backed up D3D files on XPDM -> WDDM upgrade
Guest Control: fixed setting and using a guest user’s process environment variables
Linux Additions: support Enterprise Linux 6.5 kernels (bug #12505)
Linux Additions: fixed CPU hot-remove on newer Linux kernels
Linux / Solaris Additions: don’t automount a shared folder which is already mounted
X11 Additions: support X.Org Server 1.15 (bug #12623)